Assuntos
Cálcio/sangue , Hidrocortisona/metabolismo , Adolescente , Adulto , Criança , Pré-Escolar , Síndrome de Cushing/metabolismo , Dexametasona , Feminino , Humanos , Hidrocortisona/fisiologia , Concentração de Íons de Hidrogênio , Hipercalcemia/metabolismo , Masculino , Valores de Referência , Albumina Sérica/metabolismo , UltrafiltraçãoRESUMO
A standard 4-hr ethanol infusion (236 mg/min) after a 3-day fast with and without phenformin (25 mg q.i.d.), with blood drawn every hour for 8 hr, was performed on five normal subjects, eight obese nondiabetics, seven obese chemical diabetics, and four nonobese diabetics. Control infusion induced in all subjects a decline in blood sugar levels during and/or after the alcohol challenge, with a parallel decrease in basal plasma insulin. Hypoglycemia and the decrease in insulin secretion were associated with increased plasma free fatty acid concentration. Addition of phenethylbiguanide (PBG) to the preparatory 3-day fast resulted in a greater drop in the blood glucose levels of the normal control subjects, obese and nonobese diabetics; in the obese nondiabetics, however, significantly lower degree of blood glucose decrease than control was elicited. Furthermore, obese nondiabetics altered their blood glucose-insulin interaction with apparent increased responsivess of the B cells of PBG. The results suggest that effects of phenformin on blood glucose levels are more dependent on the metabolic state of the patient than on a property of the drug itself.